Randomized Trial

Three-Level Anterior Cervical Discectomy and Fusion With or Without an Investigational Posterior Stabilization System Assessed Through 24 Months: A Multicenter Randomized Controlled Trial

Strenge, K. Brandon MD(a); Heller, Joshua E. MD(b); Williams, Daniel M. MDc; Lemons, Alexander C. MD(c); Shah, Rahul V. MD(d); Nunley, Pierce D. MD(e); Tender, Gabriel C. MD(f); Stone, Marcus B. PhD(e); McCormack, Bruce M. MD(g); Block, Jon E. PhD(h); Jenkins, Matthew B. MS(i); Slee, April E. PhD(j); Summerside, Erik M. PhD(i)

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Strenge KB, Heller JE, Williams DM, Lemons AC, Shah RV, Nunley PD, Tender GC, Stone MB, McCormack BM, Block JE, Jenkins MB, Slee AE, Summerside EM. Three-Level Anterior Cervical Discectomy and Fusion With or Without an Investigational Posterior Stabilization System Assessed Through 24 Months: A Multicenter Randomized Controlled Trial. Spine (Phila Pa 1976). 2025 Sep 1;50(17):1161-1170. doi: 10.1097/BRS.0000000000005387. Epub 2025 May 7. PMID: 40331720; PMCID: PMC12323763.

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Publication Details

In this issue of Spine, Strenge et al present the results of a randomized controlled trial evaluating outcomes in participants with three-level symptomatic cervical disc degeneration treated with either anterior cervical discectomy and fusion (ACDF) or circumferential cervical fusion (CCF). The authors maintain that this study represents the first randomized controlled trial focused on three-level cervical disc degeneration. Long-segment ACDF demonstrated low fusion rates and high rates of revision. CCF demonstrated improved fusion rates and lower rates of revision without concomitant increase in surgical morbidity.

SPINE: September 1, 2025 - Volume 50 - Issue 17
Editor-in-Chief: Andrew J. Schoenfeld, M.D.
ISSN: 0362-2436
Online ISSN: 1528-1159
Frequency: 24 issues per year
Ranking: Orthopedics 21/139; Clinical Neurology 74/285
Impact Factor: 3.5

Author Information

a. Strenge Spine Center, Paducah, KY
b. Department of Neurological Surgery and Orthopedic Surgery, Thomas Jefferson University, Philadelphia, PA
c. Department of Orthopedic Surgery, Pinehurst Surgical Clinic, Pinehurst, NC
d. Premier Orthopaedic Associates, Vineland, NJ
e. Spine Institute of Louisiana, Shreveport, LA
f. Department of Neurosurgery, Louisiana State University Health Sciences, New Orleans, LA
g. Department of Neurosurgery, University of California San Francisco, San Francisco, CA
h. Independent Consultant, San Francisco, CA
i. Department of Clinical Affairs, Providence Medical Technology, Pleasanton, CA
j. New Arch Consulting, Issaquah, WA

Permission to reproduce copyrighted Figures 1A, B have been provided by the publisher.

The device(s)/drug(s) is/are FDA-approved or approved by the corresponding national agency for this indication. This study was an FDA approved IDE Trial sponsored by Providence Medical Technology (Pleasanton, CA, USA).

K.B.S., J.H., D.W., A.L., R.S., P.N., G.T., and M.S. received institutional support for research activities. B.M. has a financial interest in the Sponsor. J.B. and A.S. received consulting fees to support research activities. M.J. and E.S. are employed by the Sponsor.

The authors report no conflicts of interest.

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